It works for me.
I can speak from my experience. I have a Dell keyboard that looks like this:
Above the Insert and Home keys there is a block of multimedia control keys: Play/Pause, Stop, Skip Back, Skip Forward.
If I have music playing in the Music app, these keys work as expected. When I use them I get visual feedback, too. In the top-left corner of the screen, where the volume display normally shows, information about what is playing is added whenever I press those multimedia keys on the keyboard.
No multimedia keyboard?
Take a look at this answer to see how to use AutoHotKey to remap available key combinations to send the multimedia key codes your keyboard cannot produce natively.