I use two OCZ Vertex's 3 in RAID1 in my server since a year with no optimisations.
I was able to use TRIM for the first time today because I upgraded to kernel 3.0.54 - CentOS 5 default kernel 2.6.18 wasn't supporting this.
discard itself should be enough to keep the drive operating properly for a long time. Make sure you've got the latest firmware which is 2.25. OCZ gives a nice tool on oczenterprise.com to upgrade SSD's without having to reboot the server.