There's almost no stand alone e-Readers that support EPUB3 quite yet. The exception might be the iPad which I heard does support some features, however I have not checked that.
If you could further define what you mean by "interactive" there might be some options to help, however most likely what you are trying to achieve using EPUB2 is just not possible and it might be a simple matter of waiting until support for EPUB3 becomes wide spread.