Are you set up for virtual machines? A scratch vm as used for testing would have the same effect.
Better yet, use an OS different from the one that was infected; e.g. a Linux VM when the drive was from an infected Windows machine.
That's safer than relying on a sandbox for extra protection in case you goof on the virus scan. Hmm, if you accidently trigger a virus, it's the main drive that needs protecting, not (just) the work drive. So why not "box" the whole thing? Restore/revert everything after you are done, just in case. (But a VM is better)